WHAT ARE PPIS?
Definition: Proton Pump Inhibitors (PPIs) are a class of medications that significantly reduce stomach acid production by blocking the enzyme system of gastric proton pumps. Purpose: They are primarily used to treat conditions related to excess stomach acid, providing relief and promoting healing in various gastrointestinal disorders.
IMPORTANCE OF PPIs
Widespread Use: PPIs are among the most commonly prescribed medications globally due to their effectiveness in managing acid-related disorders. Therapeutic Benefits: By reducing stomach acid, PPIs help in alleviating symptoms, preventing complications, and improving quality of life for patients with conditions like GERD, peptic ulcers, and more.
MECHANISM OF ACTION
Target: PPIs target and inhibit the hydrogen-potassium ATPase enzyme system, also known as the proton pump, located in the parietal cells of the stomach lining. Inhibition Process: By blocking this proton pump, PPIs prevent the final step in the production of gastric acid. Result: This inhibition leads to a significant reduction in acid secretion, helping to relieve symptoms and promote healing in acid-related gastrointestinal conditions
Symptoms Treated by PPIs
Proton Pump Inhibitors (PPIs) are used to treat a variety of symptoms associated with excess stomach acid production. Here are the common symptoms alleviated Heartburn: A burning sensation in the chest, often after eating, which might worsen at night. Regurgitation: Sour or bitter-tasting acid backing up into the throat or mouth. Dyspepsia (Indigestion): General discomfort in the upper abdomen, including bloating, nausea, and burping. Epigastric Pain: Pain located in the upper middle part of the abdomen. Nausea: Feeling of wanting to vomit, which can be related to acid-related conditions. Chronic Cough or Sore Throat: Persistent cough or sore throat caused by acid reflux irritating the throat and airways. Difficulty Swallowing (Dysphagia): A feeling of food being stuck or difficulty in swallowing due to inflammation from acid reflux.
USES of PPIs
Gastroesophageal Reflux Disease (GERD): Reduces symptoms and promotes healing of esophagitis Peptic Ulcer Disease: Helps heal ulcers in the stomach and duodenum H. pylori Eradication: Used in combination with antibiotics Zollinger-Ellison Syndrome: Manages excessive stomach acid production